The Role of Chemotherapy Combined with IMRT in the Management of Ulcerative Breast Cancer.

In July 2014, a 40-year woman presented with an enormous bleeding ulcer involving the entire left breast. The patient had pain. Modesty and fear had kept her away from looking professional help earlier, despite the lesion's presence for about 3 years. On physical examination it was found that her left breast was almost completely occupied by tumor tissue. Needle biopsy of the lump in the left breast revealed invasive breast cancer and Ki67 (50%), ER (-), PR (-), HER2 (+++) (Figure 1). Computed tomography (CT) scan identified multiple lymph nodes in her left axillary (largest measuring 1.4 cm) and a nodular lesion in the lower lobe of the right lung. Electrocardiograph, head CT, routine blood test, liver and kidney function, electrolyte, and chest X-ray film were normal. She was diagnosed as not suitable for surgery.